Successful treatment of SAPHO syndrome with zoledronic acid

Adalimumab treatment for SAPHO syndrome.

© 2010 The Authors. doi: 10.2340/00015555-0822 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 SAPHO syndrome is a rare condition of unknown pathogenesis originally described by Chamot et al. (1) in 1987. Onset usually occurs in young adults, with no differences between sexes and it is manifested by synovitis, acne, pustulosis, hyperostosis and osteitis. Of paramount impor...

A Case of Successful Treatment of Refractory Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome with Adalimumab

Synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome is a rare disease that involves the skin, bones and joints. It is thought to be caused by infection with low-toxicity bacteria and to be the result of reactive infectious osteitis. However, this hypothesis has not yet been clearly established. New SAPHO syndrome treatment methods are needed because the disease does not respond to ...

Dysregulation of P2X7 receptor-inflammasome axis in SAPHO syndrome: successful treatment with anakinra.

Francesca Barbieri, Massimiliano Parodi, Giuseppe Zampogna, Francesco Paparo and Marco A. Cimmino Dipartimento di Medicina Interna, Clinica Reumatologica and Dipartimento di Medicina Interna, Sezione di Diagnostica per Immagini, Università di Genova, Genova, Italy Accepted 12 February 2010 Correspondence to: Marco A. Cimmino, Dipartimento di Medicina Interna, Clinica Reumatologica, Università d...

SAPHO Syndrome

SAPHO syndrome treated with pamidronate.

A middle aged man presented with a 4 year history of painful swelling of both knees and pustular acne on his back. The MRI scan of the knees showed gross synovitis, so did the histopathology of the synovium. A diagnosis of SAPHO syndrome was made and he was treated with IV pamidronate. His pain reduced and acne completely cleared up on therapy. A dermatologist has rarely made a diagnosis of SAP...